Boca Juniors vs. Nacional (Thursday, 1.00am)
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After a goalless draw in the first leg of their Copa Libertadores round of 16 match Boca Juniors and Nacional both have everything to play for on Thursday.
There is very little between them which should lead to another close encounter, but unlike their previous meeting there will be a victor this time around.
We say: Boca Juniors 2-0 Nacional
There was very little to separate them in the first leg and it is likely that this will be another close game between two strong teams.
However, with the home advantage and the recent impressive defensive run that Boca Juniors have been enjoying, they will head into this one as the slight favourites.
> Click here to read our full preview for this match
Independiente vs. Dep. Pereira (Thursday, 1.00am)
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Deportivo Pereira will be attempting to progress to the quarter-finals of the Copa Libertadores on Thursday when they travel to face Independiente del Valle in their second-leg match.
The visitors head into this one with a one-nil lead to protect in this one which will force the hosts to play out in a more attacking capacity from the first whistle.
We say: Independiente del Valle 1-2 Deportivo Pereira
The fixture proved to be a close one when the teams met in the first leg, and Independiente del Valle will be sure to provide stiff competition.
However, the visitors already boast a lead and with the poor form that the hosts are in as of late Deportivo Pereira should be able to retain it and progress.
> Click here to read our full preview for this match
Palmeiras vs. Atletico Mineiro (Thursday, 1.30am)
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Palmeiras will be aiming to hold onto their 1-0 lead against Atletico Mineiro when the two sides meet in the second leg of their Copa Libertadores last-16 clash on Thursday.
Last week's visitors secured an impressive victory at Arena MRV last week, making them overwhelming favourites to advance to the quarter-finals.
We say: Palmeiras 1-0 Atletico Mineiro
Although Atletico Mineiro finally returned to winning ways at the weekend, they had been on a dreadful run of form until their victory against Sao Paulo.
Palmeiras should be able to keep their opponents at arm's length, potentially picking them off in transition should the visitors go chasing the tie after losing at home last week.