Uruguay captain Diego Lugano has been ruled out of his team's crucial World Cup encounter with England through injury.
The 33-year-old defender will miss the match in Sao Paulo on Thursday with a knee problem.
Lugano was part of the Uruguay side that suffered a surprise 3-1 defeat to Costa Rica in their opening match of the tournament.
The former West Bromwich Albion centre-back has scored nine goals in 94 games for his country since he made his debut 11 years ago.
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