Tottenham Hotspur will be out to secure a first top-flight double over the reigning champions in the Premier League era when Manchester City welcome Antonio Conte's side to the Etihad Stadium on Saturday evening.
The Lilywhites' hopes of returning to the Champions League have been dealt a trio of blows with defeats to Chelsea, Southampton and Wolverhampton Wanderers in recent weeks.
However, Spurs did manage to beat Man City 1-0 in the first gameweek of the season under Nuno Espirito Santo, with Son Heung-min netting the only goal of the contest.
Should Conte's side manage to claim all three points against the Citizens on Saturday, it will mark the first time since the 1986-87 season that they have managed to do the double over the reigning champions.
That year, Spurs marched to a pair of 1-0 victories over Liverpool, and not since November 2004 have the Lilywhites lost four Premier League games on the bounce.
Conte's men have slipped to eighth in the table ahead of Saturday's game - seven points adrift of fourth-placed Manchester United with three games in hand.
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