Arsenal, Manchester United and Tottenham Hotspur are reportedly all on high alert as Isco prepares to leave Real Madrid in this summer's transfer window.
Isco has only contributed one goal and one assist in 16 La Liga appearances for Madrid this season, having fallen out of favour at the Bernabeu since Santiago Solari arrived as head coach.
The 26-year-old has only played 17 minutes of La Liga football since the middle of January, while he did not feature in either leg of their last-16 Champions League tie against Ajax.
Last week, the Spaniard is believed to have refused to board the team bus ahead of the clash with Ajax, which Los Blancos lost 4-1 to exit the competition.
According to football.london, Arsenal, United and Tottenham are all closely monitoring developments as they consider bids in this summer's transfer window.
The Spain international has a contract at the Bernabeu until the summer of 2022.