Mason Mount could reportedly be on the sidelines for up to one month with a calf strain that he suffered during a training session with Manchester United.
The England international has found it difficult to make his mark for the 20-time English champions since arriving from Chelsea during the summer transfer window.
The attacker has only contributed one assist in 12 appearances for Man United in 2023-24, and he was absent for five matches earlier this term due to a muscular problem.
Red Devils head coach Erik ten Hag made no mention of a possible injury for Mount during his press conference on Friday to preview Sunday's contest with Everton.
However, according to the Daily Mail, the playmaker picked up a calf issue during a training session, and he could now be on the sidelines for the next three to four weeks recovering from the problem.
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Mount has not started a Premier League match for Man United since the early stages of October, and he now faces a battle to return for their festive period.
If he is absent for a month, the Englishman would miss Premier League matches against Everton, Newcastle United, Chelsea, Bournemouth, Liverpool and West Ham United, ahead of a potential return against Aston Villa on Boxing Day depending on his recovery.
Mount is also set to be ruled out of his side's final two Champions League group-stage fixtures with Galatasaray and Bayern Munich in Istanbul and Manchester respectively.
Man United have had a host of injury problems this season, and they will also be missing Casemiro, Lisandro Martinez, Jonny Evans, Christian Eriksen, Tyrell Malacia and Amad Diallo against Everton.
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Rasmus Hojlund is facing a late fitness test on the muscle strain that he suffered during the team's 1-0 win over Luton Town before the international break.
Ten Hag said during his press conference that a decision on the Denmark international's involvement at Goodison Park would be made on Saturday.
Andre Onana is fit despite suffering an injury scare while representing Cameroon, while Luke Shaw is also available after more than three months out with a muscular problem.
Shaw could come immediately back into the XI for this contest, while Victor Lindelof is set to line up alongside Harry Maguire in the middle of the defence, leaving Raphael Varane on the bench.
However, Ten Hag has firmly denied claims of a rift with Varane, who is widely expected to leave Old Trafford during next summer's transfer window.