Manchester United will host Fulham in the quarter-finals of the FA Cup, while Manchester City will welcome Burnley to the Etihad Stadium.
The Red Devils, following on from their EFL Cup success on Sunday, came from behind to record a 3-1 victory over West Ham United in the fifth round of the competition on Wednesday night.
The 20-time English champions have been handed another home draw in the quarter-finals, with fellow Premier League side Fulham set to make the trip to Old Trafford.
Man City, meanwhile, will welcome Championship leaders Burnley, who are managed by former Citizens captain Vincent Kompany.
Grimsby Town shocked Southampton on Wednesday night, recording a 2-1 victory at St Mary's, and the League Two outfit will now take on more Premier League opposition in the shape of Brighton & Hove Albion.
Sheffield United also pulled off a shock by beating Tottenham Hotspur, and the Blades have been rewarded with a home match against fellow Championship outfit Blackburn Rovers.
The last-eight ties will take place between March 17 and March 19.
Quarter-final draw in full:
Manchester City vs. Burnley
Manchester United vs. Fulham
Brighton & Hove Albion vs. Grimsby Town
Sheffield United vs. Blackburn Rovers
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