Chelsea are to entertain Manchester City in the fifth round of the FA Cup, while holders Arsenal will host Hull City in a replay of the 2014 final.
Tottenham Hotspur welcome Crystal Palace in a London derby in the next stage of the competition, and a trip to Blackburn Rovers awaits for Liverpool if they defeat West Ham United in a fourth-round replay.
Meanwhile, Manchester United will travel to League One strugglers Shrewsbury Town and Everton will visit Premier League rivals Bournemouth.
Fifth-round draw in full:
Chelsea vs. Man City
Reading vs. West Brom or Peterborough
Watford vs. Leeds
Shrewsbury vs. Man Utd
Blackburn vs. Liverpool or West Ham
Spurs vs. Crystal Palace
Arsenal vs. Hull City
Bournemouth vs. Everton
All of the games will be played between February 19 and 22.