Fulham will attempt to complete a top-flight double over Sheffield United for the first time in their history.
The Cottagers carried significant momentum into the international period, collecting three wins from their last four matches.
They produced an impressive display to ease to a 3-0 victory over Tottenham Hotspur in their final outing before the two-week break.
Fulham will return to action in 12th place and four points adrift of eighth position, which could become a European qualification spot.
They will now attempt to close that gap in Saturday's clash with relegation-threatened Sheffield United at Bramall Lane.
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The visitors will also be looking to complete their first top-flight double over the Blades after emerging victorious in October's meeting at Craven Cottage.
Bobby Decordova Reid saw his opener cancelled out in the reverse fixture, before a Wes Foderingham own goal and a Willian effort proved enough to secure a 3-1 victory.
While Fulham will be eying another victory on Saturday, they have only managed to win one of their last 10 competitive away meetings with Sheffield United (D3, L6).
The West London club fell to a 4-0 defeat in their most recent trip to Bramall Lane in a Championship fixture in May 2022.
Marco Silva's side have also struggled to produce their best form on the road this term, winning just two of their 14 away league matches (D4, L8).
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Muniz, Iwobi could be crucial to Fulham's efforts
Rodrigo Muniz and Alex Iwobi may have key roles to play if Fulham are to claim their third away league win of the season this weekend.
Muniz has scored more Premier League goals than any other player since the start of February, netting seven times in his last seven top-flight appearances.
Iwobi has also been contributing in the final third, finding the net in Fulham's last two away games against Manchester United and Wolverhampton Wanderers.
As a result of those strikes, the Nigeria international has the opportunity to follow in the footsteps of Luis Boa Morte and Heidar Helguson by becoming the third Fulham player to score in three successive Premier League away games.
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