Crystal Palace have announced that Roy Hodgson has stepped down from his post as manager.
The 76-year-old was rushed to hospital last Friday after being taken ill during a training session.
It has since been confirmed by the Eagles that Hodgson "is now out of hospital and doing well", but his spell in charge of the club has come to an end.
Hodgson's departure comes just hours before Crystal Palace face Everton in a Premier League contest at Goodison Park on Monday night.
Across two spells as Crystal Palace manager, Hodgson has taken charge of 200 games in all competitions, winning 66, drawing 46 and losing 88.
Hodgson returned to Selhurst Park in March last year following the dismissal of Patrick Vieira and successfully steered the club away from the relegation zone, securing an 11th-placed finish.
However, Crystal Palace have suffered 10 defeats in their last 16 Premier League games under Hodgson, who leaves the club sitting 16th in the table, just five points above the bottom three.
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Hodgson has bid farewell to a "very special" club and believes that now is an appropriate time to step down to allow the club to "bring forward their plans for a new manager".
A statement from Hodgson on Crystal Palace's official website read: "This club is very special and means so much to me and has played a big part in my footballing life. I have fully enjoyed my time here across six seasons, as it has given me the chance to work with top class players and staff doing what I love every day.
"However, I understand, given recent circumstances, it may be prudent at this time for the club to plan ahead, and therefore I have taken the decision to step aside so that the club can bring forward their plans for a new manager, as intended for this summer.
"I would like to thank Steve Parish and his American partners for their support, along with my coaching staff and backroom team who have helped me so much along the way. In particular, a huge thank you to my long-term friend and assistant, Ray Lewington; coaches Dean Kiely and Paddy McCarthy; plus the excellent sports science, video analysis and medical departments.
"My thanks and respect also to the current squad of players who have been a pleasure to work with - they are a credit to the club and themselves. I am certain that our fans will continue to give their full support to the team for the remainder of this season and beyond.
"I am confident that the season will finish well and I wish the team every success in the weeks, months and seasons to come."
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Crystal Palace chairman Steve Parish added: "Roy has a special place in Crystal Palace history and this will never be forgotten. After four years in which he led the club to maintaining Premier League status season after season, he once again joined us nearly a year ago to steady the ship, and worked wonders.
"That he then agreed to continue in the summer speaks volumes about his commitment to our club. Quite simply, we owe our continued Premier League status to Roy.
"I would like to thank Roy enormously for his service and wish him the very best for the future; it's fair to say Roy has the keys to Selhurst Park and will always be welcomed back.
"On a personal note I would also like to thank Roy for his support, his professionalism and his friendship. He's been the manager for half of the time we've been in the Premier League, I've enjoyed working with him and learning from him immensely."
It has been widely reported that Austrian manager Oliver Glasner, formerly of former Eintracht Frankfurt, will succeed Hodgson at Selhurst Park.
Palace have confirmed that assistant coaches Paddy McCarthy and Ray Lewington will lead the team for Monday's clash against Everton.