Charlotte FC vs. Inter Miami (Saturday, 8.30pm)
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On Saturday, Charlotte FC and Inter Miami will meet for the first time in Major League Soccer at Bank of America Stadium in North Carolina.
The Crown are winless in their last three domestic affairs, while the Herons saw a four-match winning run in all competitions come to an end in their previous encounter, losing 2-0 to the New England Revolution.
We say: Charlotte FC 2-0 Inter Miami
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Montreal vs. Orlando City (Saturday, 9.00pm)
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With a win or draw on Saturday versus Orlando City at Saputo Stadium, CF Montreal would set a new record for the longest unbeaten run in franchise history since joining Major League Soccer in 2012.
A goal eight minutes from the end increased the Montreal undefeated streak to six games domestically, while the Lions have won three of their last four MLS affairs, defeating Charlotte FC 2-1 on Saturday.
We say: CF Montreal 1-1 Orlando City
Montreal have plenty of momentum heading into this encounter, though they have struggled in previous fixtures against the Lions, winning only once in their last six meetings.
Given how well each team defend without the ball, we expect there will be little time or space for the creative players on each side to make some magic happen, and there is unlikely to be a lot of chances at either end of the field.
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Atlanta vs. Chicago Fire (Saturday, 11.00pm)
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A pair of struggling Major League Soccer teams face off on Saturday as Atlanta United host the Chicago Fire at Mercedes-Benz Stadium.
The Five Stripes have picked up just a single point in their previous four MLS encounters, while Chicago are winless in their last six matches played in all competitions.
We say: Atlanta United 1-0 Chicago Fire
Neither side are in good form at the moment, but we expect that home field will tip the scales in the favour of Atlanta.
The Fire should be a tough team to break down defensively once again, however they invite a lot of pressure into their third of the field, and we expect the Five Stripes to eventually find a way to score and end their current winless skid.
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NY Red Bulls vs. Portland (Sunday, 12.00am)
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The New York Red Bulls have a chance to extend their winning run to four games in all competitions when they host the Portland Timbers on Saturday at Red Bull Arena.
Over the weekend, New York scored a pair of late goals to claim a 2-1 win against the Chicago Fire, while the Timbers failed to capitalise on their man-advantage in the Rockies, dropping a 2-0 decision to the Colorado Rapids.
We say: New York Red Bulls 2-1 Portland Timbers
The Timbers are not as bad as their record may indicate, but they always seem to allow one too many quality scoring opportunities in their own third of the field.
New York do not create a ton of chances in front of goal, but when they do, they have usually been able to make them count.
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NY City vs. Kansas (Sunday, 12.00am)
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New York City FC have a chance to match their longest winning run from the 2021 regular season of Major League Soccer when they host Sporting Kansas City on Saturday at Citi Field.
The Pigeons have won three consecutive league fixtures, and currently sit fifth in the Eastern Conference, while SKC have failed to win five straight contests, their longest regular-season stretch without a victory since 2019.
We say: New York City FC 3-1 Sporting Kansas City
NYCFC can do no wrong at the moment, and they have been relentless on the press, making other teams pay for their giveaways.
Sporting are a wounded animal right now, which the Boys in Blue should be able to take advantage of as New York have not shown any mercy when smelling blood.
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DC United vs. Houston (Sunday, 12.30am)
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DC United return to Audi Field in search of their first win against the Houston Dynamo since 2014 when the two sides face each other in Major League Soccer action on Saturday.
The Black and Red ended the month of April with a 3-0 defeat on the road to the Columbus Crew, while Orange Crush have dropped consecutive fixtures by a 2-1 score.
We say: DC United 1-2 Houston Dynamo
On paper, DC have more individual quality than the Dynamo, although they have only shown that in small sample sizes this season, whereas Houston have been more consistent and structurally sound so far in 2022.
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New England vs. Columbus Crew (Sunday, 12.30am)
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New England Revolution will be aiming for consecutive victories this Sunday when they welcome Columbus Crew to the Gillette Stadium.
The visitors are undefeated in their previous two Major League Soccer matches, and they have the possibility of moving up to fifth in the table with a win this weekend.
We say: New England Revolution 1-2 Columbus Crew
Both teams have suffered lengthy runs without a victory as of late, but they head into this match having brought those to an end.
That should bring confidence to them, and it will lead to a closely-fought game, yet the visitors should just be able to steal all three points due to their slightly stronger defensive qualities.
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Minnesota Utd vs. Cincinnati (Sunday, 1.00am)
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FC Cincinnati will be looking to extend their winning run to three games on Sunday when they travel to Allianz Field to face Minnesota United in their latest Major League Soccer game.
The hosts suffered a defeat in midweek, but they have the potential of climbing into third place of the Western Conference if they can secure three points.
We say: Minnesota United 1-2 FC Cincinnati
Both of these teams have had similar seasons so far, playing confidently within their respective divisions which is why they are each in the playoff spots.
However, recent form does favor the visitors, and their ability to keep clean sheets while still being offensively impressive could be enough to give them the edge.
No Data Analysis info
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Dallas vs. Seattle (Sunday, 1.30am)
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Two teams at opposite ends of the Major League Soccer Western Conference will meet on Sunday when Dallas welcome Seattle Sounders to the Toyota Stadium.
The visitors are currently bottom of the table, but they have momentum from winning the CONCACAF Champions League in midweek.
We say: Dallas 2-1 Seattle Sounders
The visitors might have some extra confidence after lifting silverware in midweek, but their league form is difficult to look past at the moment.
On the other hand, Dallas have been impressive in the league, and they should be able to extend their undefeated run at home this season on Sunday.
No Data Analysis info
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Earthquakes vs. Colorado (Sunday, 3.00am)
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San Jose Earthquakes will be out to try and win their second Major League Soccer game of the season this Sunday when they welcome Colorado Rapids to PayPal Park.
On the other hand, the visitors have the potential of pushing into the playoff positions with a victory on Sunday.
We say: San Jose Earthquakes 0-3 Colorado Rapids
San Jose Earthquakes have struggled so far this season, and their poor performances have been reflected in their current league position heading into this match.
Their defensive issues have been a big problem so far, and their inability to keep a clean sheet should allow Colorado Rapids to pick up all three points here.
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Los Angeles vs. Philadelphia (Sunday, 4.00am)
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The league leaders of the Major League Soccer Eastern and Western Conferences will meet each other this Sunday as Philadelphia Union travel to play Los Angeles FC.
Each team has lost just once so far this season, although it is the hosts that are in stronger form heading into this one.
We say: Los Angeles FC 2-1 Philadelphia Union
These are the two top Major League Soccer teams so far, and they will be wanting to establish their early dominance at the expense of their opponents on Sunday.
However, the visitors have been suffering a difficult spell in recent matches, and that could provide Los Angeles the chance to gain all three points here.