B. Leverkusen vs. Union Berlin (Sunday, 2.30pm)
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Bayer Leverkusen will be aiming to win their seventh successive game in the Bundesliga when they host Union Berlin on Sunday.
The visitors finally ended their 12-match losing streak in all competitions by drawing away to Napoli in the Champions League on Wednesday, but they will head into this match occupying the relegation places.
We say: Bayer Leverkusen 2-1 Union Berlin
In terms of form, this could be the biggest mismatch in European football this weekend, but that does not paint the full picture. Union Berlin are a much better team than they have shown so far this season, and their confidence will have been boosted by drawing away to Serie A champions Napoli in midweek.
However, Leverkusen are a serious attacking force at present and have more strings to their bow in terms of breaking their opponents down. While we can envisage the visitors making Leverkusen work hard for their victory, especially having travelled back from Azerbaijan less than 72 hours prior to this fixture, they should have enough to get over the line in the end and remain at the top of the table.
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Werder Bremen vs. Frankfurt (Sunday, 4.30pm)
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Werder Bremen will be aiming to make it four wins from five home games in the Bundesliga when they host Eintracht Frankfurt on Sunday.
The visitors, meanwhile, have improved in recent weeks to claim 10 points from their last four matches.
We say: Werder Bremen 2-2 Eintracht Frankfurt
Only Bayern Munich have posted a stronger defensive record than Frankfurt after the opening 10 games, but Toppmoller's side will be tested by Werder Bremen's attacking potency, especially having competed in Europe on Thursday evening.
Only VfL Bochum have drawn as many games as Frankfurt (five) after 10 matches this season, and we can envisage the visitors having to share the spoils once again in an entertaining encounter, which is a result neither manager would likely be disappointed with.
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RB Leipzig vs. Freiburg (Sunday, 6.30pm)
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RB Leipzig will be determined to return to winning ways in the Bundesliga when they host Freiburg on Sunday.
The visitors, meanwhile, remain in the top half of the table despite failing to win either of their last two league matches.
We say: RB Leipzig 2-0 Freiburg
After suffering two disappointing defeats on the road, Leipzig will have taken plenty of confidence from their hard-earned victory away from home in the Champions League in midweek, and they will be pleased to be back at the Red Bull Arena on Sunday.
Freiburg have had two fewer days' rest than their forthcoming opponents after winning in the Europa League on Thursday, and although we expect them to remain competitive as is usually the case, we can envisage Leipzig securing a relatively routine win.