England have set Ireland a total of 202 for victory after recording a score of 201-8 during the one-day international in Dublin.
Jonathan Trott was the visitors' top scorer with a knock of 69, while stand-in captain Eoin Morgan registered a score of 59.
John Mooney was the most productive bowler for the home side, ending the innings with figures of 3-32.
A rain delay has reduced the match to 42 overs per side.